These are the major and minor Huffer/Hoffer/... family lines which have been at least partially traced as of:
13 April 2015

Descendants of Johannes Hoffert (my 5th great-grandfather; born 1700-1730 in Germany, died 1788-90 in Berks County PA; descendants (Huffer, Hoffert) have settled in Pennsylvania, Virginia, Ohio, Illinois)

Descendants of Johannes Hofer (born ? in Switzerland, died Washington County MD sometime after 1780; many descendants (mostly Huffers) from Frederick and Washington Counties MD)

Descendants of Daniel Hoffer (born in PA, probably around 1780 +-; died about 1839 in Fairfield County OH; most heirs retained the "Hoffer" spelling of the name; might be related to Johannes Hoffert but I have not been able to establish a connection; Giles & Mary Hoffer published a 484-page genealogy of this family in 1975)

Descendants and Ancestors of Christian Hoffart(h) (born in Germany 1716, died in Frederick County MD in 1788; Christian's descendants have variously spelled their name Hoffart, Hoffert, Hufford and Hufferd; most of the information on this family comes from the work of Alice Marie Beard).
Added to this line is the Hartsing family of Germany and Wood County OH.  Two of Christian Hartsing's sons (George and Michael) married Hufford sisters, Susan and Elizabeth, daughters of Jacob Staley Hoffert (1798-1884) of Wood County OH (added 6/19/2012).

Descendants of Joseph Hoffer (born before 1755, died 1812 Lancaster County PA; grandson Abraham Hoffer/Huffer settled in Greene County OH and named a community Huffersville, a town which is long gone)

Descendants of Jacob Huffer (born 1780-90; lived in KY before 1810, later moved to Clermont County OH; I have limited information on this line, a few 5th-generation Huffers in Bartholomew County IN in the early 1900's; no leads on Jacob's ancestry in this country or abroad)

Descendants of Samuel Huffer (born 1785 PA, died 1864 Hancock County IN; father may have been Jacob, but no further data on his ancestors; 7th and a few 8th generation descendants, IN and elsewhere)

Descendants of John Huffer (born 1800-1810 IN; died 1839 Fountain County IN; possibly a son of Abraham Hoffer of Bath Twp, Green County OH; 7th-generation descendants in Fountain County IN, WI, MN, NB, WY, elsewhere

Descendants of William Cobb Hufford (born 1805 or 1809 in TN; lived in AL and GA; several generations in TX and CA use the name Huffor)

Descendants of John G. Hoffer (born about 1810 in France; found in Erie County NY in 1850 & 1860; I have only traced a few of the 6th-generation Hoffers in this line).

Descendants of Daniel Huffer of Roane County TN (born 1820-25; "went missing when the children were small"; 6th-generation descendants in TN, OK and elsewhere)

Descendants of John Hoffer (born 1782 Westmoreland County PA; died 1851 Holmes County OH; many heirs retained the "Hoffer" spelling of the name; I have been unable to establish John's ancestry in the U.S. or his immigrant ancestors)

Descendants of William Huffer (born 1828 in England, immigrated in 1857, died 1894 in Jasper County MO).  I have 4 generations, mostly living in Missouri.

Descendants of Georg Hoffer (born ca. 1835 in Bayern, living in New York City by 1861)

Several English Huffer families, including ancestors of Arthur Huffer (1887-1972) of Westmoreland County PA (interestingly, both of Arthur's parents were Huffers, from different families in Hertfordshire County England!);
also descended from the same line of English Huffers is George R. Huffer (1836-?) of Monroe County NY.
Recently added:  some descendants of William Huffer (b. abt 1534 Bourne, Lincolnshire, England)

French Huffers!  Descendants of Leopold Huffer, b. 1825 in Germany, immigrated to the U.S. and lived in New York around 1850.  Many or most of his descendants (at least 3 sons, 1 daughter) lived and worked in Paris, France; later generations remained in France.

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Please contact me at chuffer123@gmail.com if you have questions or information you would like to share!
Chuck Huffer
Thousand Oaks, CA
www.HufferFamily.com/tng
HufferFamilies2013June28 Family Tree on www.Ancestry.com